tert-butyl (2R,3S)-3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate → 2-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride, (2R,3S)-

HRID 1864509노트

반응식

HRID 1864509 반응식
[OH:1][C@H:2]1[CH2:6][CH2:5][N:4](C(OC(C)(C)C)=O)[C@@H:3]1[CH2:14][OH:15].[ClH:16].C[C@H]1CCN[C@@H]1CO>>[ClH:16].[OH:15][CH2:14][C@@H:3]1[C@@H:2]([OH:1])[CH2:6][CH2:5][NH:4]1

참가 물질

3

반응물 2

HCID 10910976tert-butyl (2R,3S)-3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylateHCID 57463460HCID 57463460, 화합물

생성물 1

HCID 156073442-Pyrrolidinemethanol, 3-hydroxy-, hydrochloride, (2R,3S)-

실험 절차

The title compound was prepared from 1,1-dimethylethyl (2R, 3S)-3-hydroxy-2-(hydroxymethyl)-1-pyrrolidinecarboxylate using the methods used to prepare [(2S,3S)-3-methyl-2-pyrrolidinyl]methanol hydrochloride. 1H NMR (400 MHz, DMSO-D6) δ ppm 1.8 (m, 1H), 2.0 (m, 1H), 2.5 (m, 2H), 3.2 (m, 2H), 3.3 (m, 1H), 3.5 (m, 1H), 3.6 (m, 1H), 4.1 (m, 1H), 8.7 (s, 1H), 9.5 (m, 1H). ES+=117.97.

출처 및 근거

ORD 기록
ord-6b703e435b54497e97a421a205593baa
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07625909B2

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