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Thiazolidinedione → HCID 86606241、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thiazolidinedione | HCID 5437 | — |
| 反応物 | Piperidinium acetate | HCID 3014295 | — |
| 反応物 | Tert-butyl[3-(5-formylthiophen-2-yl)benzyl]methylcarbamate | HCID 86606242 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | HCID 86606241 | HCID 86606241 | 76% |
反応手順
A solution of 2.4 g (7.2 mmol) of tert-butyl [3-(5-formylthiophen-2-yl)benzyl]methylcarbamate, 0.85 g (7.2 mmol) of 2,4-thiazolidinedione and 0.2 g (1.4 mmol) of piperidinium acetate in 50 ml of toluene is refluxed for 4 hours in Dean-Stark apparatus. After cooling, the product precipitates. The precipitate is filtered off and washed with ethyl ether. 2.3 g (76%) of tert-butyl {3-[5-(2,4-dioxothiazolidin-5-ylidenemethyl)thiophen-2-yl]benzyl}methylcarbamate are obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07625914B2 |
| 出典データセット | uspto-grants-2009_12 |
| ORD ID | ord-fe8df232445e4730bf42fb93d6c3bb64 |
| 出典メモ | uspto-grants-2009_12 |