(6-Iodopyridin-3-yl)methanol → 6-Iodopyridine-3-carbaldehyde

HRID 1864572노트

반응식

HRID 1864572 반응식
[I:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][OH:9])=[CH:4][CH:3]=1>ClCCl.[O-2].[O-2].[Mn+4]>[I:1][C:2]1[N:7]=[CH:6][C:5]([CH:8]=[O:9])=[CH:4][CH:3]=1

참가 물질

4

반응물 1

HCID 23039516(6-Iodopyridin-3-yl)methanol

생성물 1

HCID 534852236-Iodopyridine-3-carbaldehyde

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매2회

실험 절차

63 g (723 mmol) of manganese dioxide are added to a solution of 17 g (72 mmol) of (6-iodopyrid-3-yl)methanol in 600 ml of dichloromethane. The reaction medium is stirred at room temperature for 20 hours and then filtered through Celite. The precipitate is washed thoroughly with water and the filtrate is evaporated under vacuum. The residue obtained is taken up in dichloromethane and the insoluble material is again filtered off. After evaporation of the filtrate, 13.2 g (78%) of 6-iodopyridine-3-carbaldehyde are obtained in the form of a pale yellow solid with a melting point of 141° C.

후처리

  1. filtrationfiltered through Celite
  2. washThe precipitate is washed thoroughly with water
  3. customthe filtrate is evaporated under vacuum
  4. customThe residue obtained
  5. filtrationthe insoluble material is again filtered off
  6. customAfter evaporation of the filtrate, 13.2 g (78%) of 6-iodopyridine-3-carbaldehyde
  7. customare obtained in the form of a pale yellow solid with a melting point of 141° C.

출처 및 근거

ORD 기록
ord-fcd6b61a62354943b0685c981a0713b1
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07625914B2

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