2-Naphthylamine → 1-Chloro-naphthalen-2-ylamine

HRID 1864608

반응식

HRID 1864608 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[NH2:11].C1C(=O)N([Cl:19])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Cl:19][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[NH2:11]

참가 물질

4

반응물 2

HCID 70572-NaphthylamineHCID 31398Chlorosuccinimide

생성물 1

HCID 4180141-Chloro-naphthalen-2-ylamine수율 96.2%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

반응 조건

온도
49 °C

실험 절차

To a CCl4 (600 mL) solution of 2-naphthylamine (10 g) at 49° C. was added NCS (9.51 g, 1.02 eq) in portions. The mixture was stirred at 49° C. for 1.5 h then concentrated to dryness to give 1-chloro-2-naphthylamine (11.94 g, 96%) as a dark solid. MS Found: (M+H)+=178.

후처리

  1. concentrationthen concentrated to dryness

출처 및 근거

ORD 기록
ord-b3aa8510d4024a85bb81e219ef6b4778
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07625921B2

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