6-(6-Bromo-2,3,4-trifluorophenyl)-3,3-dimethylpiperidin-2-one → 3,3-Dimethyl-6-(2,3,4-trifluorophenyl)piperidin-2-one
반응식
Br[C:2]1[C:7]([CH:8]2[NH:13][C:12](=[O:14])[C:11]([CH3:16])([CH3:15])[CH2:10][CH2:9]2)=[C:6]([F:17])[C:5]([F:18])=[C:4]([F:19])[CH:3]=1>[Pd].CCO>[CH3:15][C:11]1([CH3:16])[CH2:10][CH2:9][CH:8]([C:7]2[CH:2]=[CH:3][C:4]([F:19])=[C:5]([F:18])[C:6]=2[F:17])[NH:13][C:12]1=[O:14]참가 물질
4
실험 절차
A solution of 6-(6-bromo-2,3,4-trifluorophenyl)-3,3-dimethylpiperidin-2-one (27.0 mg, 0.080 mmol, described in Intermediate 17) and 10% palladium on carbon in degassed EtOH (2 mL) was stirred under a hydrogen balloon for 3 h. The reaction mixture was filtered through a Celite pad and concentrated in vacuo to provide the title compound. MS: m/z=258 (M+1).
후처리
- filtrationThe reaction mixture was filtered through a Celite pad
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-aa802142768d48f1aa1d871cf556ed06
- 출처 데이터셋
- uspto-grants-2009_12
- 특허 번호
- US07625901B2
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