Methyl vinyl ketone → 1-{4-[2-(3-Bromo-phenyl)-5-methyl-pyrrol-1-yl]-benzenesulfonyl}-piperidine

HRID 18649

반응식

[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:10][C:11](=O)[CH:12]=[CH2:13].[N:15]1([S:21]([C:24]2[CH:29]=[CH:28][C:27]([NH2:30])=[CH:26][CH:25]=2)(=[O:23])=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[Br:1][C:2]1[CH:3]=[C:4]([C:5]2[N:30]([C:27]3[CH:28]=[CH:29][C:24]([S:21]([N:15]4[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]4)(=[O:23])=[O:22])=[CH:25][CH:26]=3)[C:11]([CH3:10])=[CH:12][CH:13]=2)[CH:7]=[CH:8][CH:9]=1

참가 물질

반응물 3

HCID 6570Methyl vinyl ketone

HCID 765833-Bromobenzaldehyde

HCID 2366484-(Piperidine-1-sulfonyl)aniline

생성물 1

HCID 684870551-{4-[2-(3-Bromo-phenyl)-5-methyl-pyrrol-1-yl]-benzenesulfonyl}-piperidine

실험 절차

3-Bromobenzaldehyde and but-3-en-2-one were treated according to the procedure outlined in General Procedure C followed by subjecting the resulting product to conditions outlined in General Procedure D along with p-piperidinylsulfonyl phenylamine to obtain the titled compound. 1H NMR (CDCl3) δ ppm 1.45-1.60 (6H), 2.18 (3H), 3.05 (4H), 6.18 (1H), 6.40 (1H), 7.05-7.90 (8H); MS (ESI) m/z 459/461 (M+H).

출처 및 근거

ORD 기록: ord-0c06ff66ed38422aa825235aa32aff0d
출처 데이터셋: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07741364B2

연결된 노트

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