Boron tribromide → Ethyl 3-hydroxy-4-methylphenylacetate
반응식
C[O:2][C:3]1[CH:4]=[C:5]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:6]=[CH:7][C:8]=1[CH3:9].B(Br)(Br)Br>C(Cl)Cl>[OH:2][C:3]1[CH:4]=[C:5]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:6]=[CH:7][C:8]=1[CH3:9]참가 물질
4
반응 조건
- 온도
- -78 °C
실험 절차
step 3—To a solution of 4c (2.2 g; 8.0 mmol) and 250 mL CH2Cl2 cooled to −78° C. was added dropwise via syringe BBr3 (9.8 mL; 0.104 mol). After 1 h at −78° C. the reaction was stirred for 4 h in an ice-water bath. The reaction mixture was recooled to −78° C. and the reaction quenched aqueous NaHCO3 then warmed to rt and the organic phase washed with water, saturated NaHCO3 and brine. The organic phase was dried (MgSO4) and the solvent evaporated to afford 1.4 g of ethyl 3-hydroxy-4-methylphenylacetate (6).
후처리
- customwas recooled to −78° C.
- customthe reaction quenched aqueous NaHCO3
- temperaturethen warmed to rt
- washthe organic phase washed with water, saturated NaHCO3 and brine
- dry with materialThe organic phase was dried (MgSO4)
- customthe solvent evaporated
출처 및 근거
- ORD 기록
- ord-89886f92d97c407c9b82a2a3adfe3655
- 출처 데이터셋
- uspto-grants-2009_12
- 특허 번호
- US07625949B2
반응 노트
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