Acetic Acid → 2-[(4-Methylphenyl)sulfonyl]-3-[4-(3-methylthio(2-thienyl))phenyl]prop-2-enenitrile

HRID 1865127

반응식

HRID 1865127 반응식
[CH3:1][S:2][C:3]1[CH:7]=[CH:6][S:5][C:4]=1[C:8]1[CH:15]=[CH:14][C:11]([CH:12]=O)=[CH:10][CH:9]=1.[C:16]1([CH3:28])[CH:21]=[CH:20][C:19]([S:22]([CH2:25][C:26]#[N:27])(=[O:24])=[O:23])=[CH:18][CH:17]=1.N1CCCCC1.C(O)(=O)C>C1(C)C=CC=CC=1>[CH3:28][C:16]1[CH:17]=[CH:18][C:19]([S:22]([C:25](=[CH:12][C:11]2[CH:14]=[CH:15][C:8]([C:4]3[S:5][CH:6]=[CH:7][C:3]=3[S:2][CH3:1])=[CH:9][CH:10]=2)[C:26]#[N:27])(=[O:24])=[O:23])=[CH:20][CH:21]=1

참가 물질

6

반응물 4

HCID 176Acetic AcidHCID 8082PiperidineHCID 79776TosylacetonitrileHCID 57975359HCID 57975359, 화합물

생성물 1

HCID 690201762-[(4-Methylphenyl)sulfonyl]-3-[4-(3-methylthio(2-thienyl))phenyl]prop-2-enenitrile

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

To a stirring solution of 4-(3-methylthio-2-thienyl)benzaldehyde (1.0 mmol, prepared directly above) and p-toluenesulphonylacetonitrile (1.0 mmol) in toluene, add piperidine (0.05 mmol) and acetic acid (0.3 mmol). Heat the reaction mixture to reflux for 2 hours while using a Dean-Stark trap, remove the heat and concentrate the reaction in vacuo. The crude material can be carried on to the next step without further purification.

후처리

  1. temperatureHeat the reaction mixture
  2. temperatureto reflux for 2 hours
  3. customremove the
  4. temperatureheat
  5. concentrationconcentrate
  6. customthe reaction in vacuo
  7. customThe crude material can be carried on to the next step without further purification

출처 및 근거

ORD 기록
ord-e678d31c3812410c82607739188924b7
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07625932B2

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