1-Chloro-2-ethynyl-4-(trifluoromethyl)benzene → 3-[2-Chloro-5-(trifluoromethyl)phenyl]-1-(7-methoxyquinolin-3-yl)prop-2-yn-1-one
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[C:12]#[CH:13].CON(C)[C:17]([C:19]1[CH:20]=[N:21][C:22]2[C:27]([CH:28]=1)=[CH:26][CH:25]=[C:24]([O:29][CH3:30])[CH:23]=2)=[O:18]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:9])([F:10])[F:11])=[CH:4][C:3]=1[C:12]#[C:13][C:17]([C:19]1[CH:20]=[N:21][C:22]2[C:27]([CH:28]=1)=[CH:26][CH:25]=[C:24]([O:29][CH3:30])[CH:23]=2)=[O:18]참가 물질
3
실험 절차
The title compound was prepared with the alkyne from step B and N,7-dimethoxy-N-methylquinoline-3-carboxamide the intermediate from example 2 step E following the procedure described in example 2 step F. 1H NMR (CDCl3, 500 MHz): 9.62 (d, J=2.1 Hz, 1H), 8.97 (d, J=2.1 Hz, 1H), 8.03 (s, 1H), 7.87 (d, J=8.9 Hz, 1H), 7.69 (d, J=3.0 Hz, 2H), 7.51 (d, J=2.3 Hz, 1H), 7.31 (dd, J=2.3, 8.9 Hz, 1H), 4.03 (s, 3H). LC-MS: 3.85 min. (M+H)=389.9.
후처리
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