Ethanol → HCID 178482750, 화합물

HRID 1865644노트

반응식

HRID 1865644 반응식
[Br:1][C:2]1[CH:3]=[C:4]([C:9](=O)[CH2:10][C:11]2[CH:16]=[CH:15][C:14]([N:17]([CH3:19])[CH3:18])=[CH:13][CH:12]=2)[C:5](F)=[N:6][CH:7]=1.C(O)C.[NH2:24][NH2:25]>O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9]([CH2:10][C:11]3[CH:16]=[CH:15][C:14]([N:17]([CH3:19])[CH3:18])=[CH:13][CH:12]=3)=[N:25][NH:24][C:5]2=[N:6][CH:7]=1

참가 물질

5

반응물 3

HCID 702EthanolHCID 9321HydrazineHCID 579757321-(5-Bromo-2-fluoro-3-pyridinyl)-2-[4-(dimethylamino)phenyl]ethanone

생성물 1

HCID 178482750HCID 178482750, 화합물수율 57.2%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1-(5-Bromo-2-fluoro-pyridin-3-yl)-2-(4-dimethylamino-phenyl)-ethanone (890 mg, 2.64 mmol), ethanol (100 ml), and anhydrous hydrazine (0.4 ml, 12.74 mmol) were combined and stirred for 18 hours at room temperature. The reaction was diluted with water and the precipitate filtered and dried to obtain 500 mg (57%) of [4-(5-bromo-1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-phenyl]-dimethyl-amine. MS m/z 331.1+333.1 (M+H+).

후처리

  1. filtrationthe precipitate filtered
  2. customdried

출처 및 근거

ORD 기록
ord-f60b1d76abc8431abf8be27daba288fa
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07626021B2

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