2-Chlorotrityl chloride → HNle 2-chlorotrityl resin
반응식
[NH:1](C(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O)[C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH2:4][CH2:5][CH3:6].[CH:27]1[CH:32]=[CH:31][C:30]([C:33]([Cl:47])([C:40]2[C:45]([Cl:46])=[CH:44][CH:43]=[CH:42][CH:41]=2)[C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[CH:29][CH:28]=1>>[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH2:4][CH2:5][CH3:6].[CH:37]1[CH:36]=[CH:35][C:34]([C:33]([Cl:47])([C:40]2[C:45]([Cl:46])=[CH:44][CH:43]=[CH:42][CH:41]=2)[C:30]2[CH:31]=[CH:32][CH:27]=[CH:28][CH:29]=2)=[CH:39][CH:38]=1참가 물질
3
실험 절차
The resin was prepared using similar methodology to that described in Example 2 step 2.3 from FmocNleOH (4.37 g) and 2-chlorotrityl chloride resin (7.45 g, 0.83 mmol/g, Novabiochem) to yield 7.77 g HNle-2-chlorotrityl resin (loading: 0.50 mmol/g).
후처리
- customThe resin was prepared
출처 및 근거
- ORD 기록
- ord-825d9db8764147b397a8dec195698e7f