Dimethylamine → 4-(2-Furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine
반응식
[NH2:1][C:2]1[N:7]=[C:6]2[N:8](C(OC(C)(C)C)=O)[N:9]=[CH:10][C:5]2=[C:4]([C:18]2[O:19][CH:20]=[CH:21][CH:22]=2)[N:3]=1.CNC>CO.O>[O:19]1[CH:20]=[CH:21][CH:22]=[C:18]1[C:4]1[N:3]=[C:2]([NH2:1])[N:7]=[C:6]2[NH:8][N:9]=[CH:10][C:5]=12참가 물질
5
실험 절차
A solution of tert-butyl 6-amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate (204 mg, 0.68 mmol) in MeOH (2 mL) was treated with dimethylamine in water (0.5 mL, 40%), refluxed for 1 h, cooled and the resulting solid filtered and washed with water to give the title compound (95 mg, 70%) as a cream solid.
후처리
- temperaturerefluxed for 1 h
- temperaturecooled
- filtrationthe resulting solid filtered
- washwashed with water
출처 및 근거
- ORD 기록
- ord-a601e26dc6a3431b9ac4f2f290c6a713
- 출처 데이터셋
- uspto-grants-2009_12
- 특허 번호
- US07629349B2
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