Dimethylamine → 4-(2-Furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine

HRID 1865899

반응식

HRID 1865899 반응식
[NH2:1][C:2]1[N:7]=[C:6]2[N:8](C(OC(C)(C)C)=O)[N:9]=[CH:10][C:5]2=[C:4]([C:18]2[O:19][CH:20]=[CH:21][CH:22]=2)[N:3]=1.CNC>CO.O>[O:19]1[CH:20]=[CH:21][CH:22]=[C:18]1[C:4]1[N:3]=[C:2]([NH2:1])[N:7]=[C:6]2[NH:8][N:9]=[CH:10][C:5]=12

참가 물질

5

반응물 2

HCID 674DimethylamineHCID 22015534tert-Butyl 6-amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate

생성물 1

HCID 220155004-(2-Furyl)-1H-pyrazolo[3,4-d]pyrimidine-6-amine수율 70%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

A solution of tert-butyl 6-amino-4-(2-furyl)-1H-pyrazolo[3,4-d]pyrimidine-1-carboxylate (204 mg, 0.68 mmol) in MeOH (2 mL) was treated with dimethylamine in water (0.5 mL, 40%), refluxed for 1 h, cooled and the resulting solid filtered and washed with water to give the title compound (95 mg, 70%) as a cream solid.

후처리

  1. temperaturerefluxed for 1 h
  2. temperaturecooled
  3. filtrationthe resulting solid filtered
  4. washwashed with water

출처 및 근거

ORD 기록
ord-a601e26dc6a3431b9ac4f2f290c6a713
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07629349B2

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