2-Chloro-1-(4-methylpiperazin-1-yl)ethanone → 1'-({6-Chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

HRID 1865931

반응식

HRID 1865931 반응식
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][C:25]([F:27])=[CH:26][C:21]=5[C:20](=[O:28])[O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7][NH:8]2)=[CH:4][CH:3]=1.Cl[CH2:30][C:31]([N:33]1[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]1)=[O:32]>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([C:11]([N:13]3[CH2:18][CH2:17][C:16]4([C:22]5[CH:23]=[CH:24][C:25]([F:27])=[CH:26][C:21]=5[C:20](=[O:28])[O:19]4)[CH2:15][CH2:14]3)=[O:12])=[CH:7][N:8]2[CH2:30][C:31]([N:33]2[CH2:38][CH2:37][N:36]([CH3:39])[CH2:35][CH2:34]2)=[O:32])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 8181732-Chloro-1-(4-methylpiperazin-1-yl)ethanoneHCID 596576231'-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

생성물 1

HCID 596576401'-({6-Chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indol-3-yl}carbonyl)-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one

실험 절차

Following the general procedure V as described hereinabove, the alkylation of 1′-[(6-chloro-1H-indol-3-yl)carbonyl]-5-fluoro-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (the preparation of which have been described in example 19) with commercially available 2-chloro-1-(4-methyl-piperazin-1-yl)-ethanone as electrophile, the title compound was obtained as a white solid. ES-MS m/e (%): 539.4 (M+H+).

출처 및 근거

ORD 기록
ord-97ee2c3eb90d4e7fbe7264697a4972ea
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07629353B2

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