Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzamide → N-(4-bromobenzenesulfonyl)benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzamide | HCID 2331 | — |
| 반응물 | p-Bromobenzenesulfonyl chloride | HCID 7396 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-(4-bromobenzenesulfonyl)benzamide | HCID 766162 | 52.7% |
반응 단계
To a solution of benzamide (1.42 g) in tetrahydrofuran (50 ml) were added sodium hydride (611 mg) and 4-bromobenzenesulfonyl chloride (3.0 g), and the mixture was stirred at room temperature for 3 hours. The mixture was diluted with ethyl acetate and water. The organic layer was separated, washed with brine, dried over magnesium sulfate and evaporated. The residue was purified by column chromatography on silica gel (hexane/ethyl acetate=2/1) to give N-benzoyl-4-bromobenzenesulfonamide (2.1 g) as a colorless powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07629366B2 |
| 출처 데이터셋 | uspto-grants-2009_12 |
| ORD ID | ord-e3a478b86361440582b448e09be22cac |
| 출처 메모 | uspto-grants-2009_12 |