Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Fluoro-4-morpholinoaniline → (2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Fluoro-4-morpholinoaniline | HCID 1485330 | — |
| 반응물 | (-)-Epichlorohydrin | HCID 2734062 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | (2R)-1-Chloro-3-[[3-fluoro-4-(4-morpholinyl)phenyl]amino]-2-propanol | HCID 16655948 | 99.3% |
반응 단계
3-Fluoro-4-morpholinyl aniline (39 g) is mixed with R-epichlorohydrin (18.5 g), isopropyl alcohol (200 ml) is added and heated for 16 hours at reflux temperature. The solvent is distilled to give 57 gm of N-[3-Chloro-2-(R)-hydroxypropyl]-3-fluoro-4-morpholinyl aniline.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07741480B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-be059e33dcdc4ec49c1e9eb1e2a24b02 |
| 출처 메모 | uspto-grants-2010_06 |