HCID 66865136, 화합물 → HCID 57974031, 화합물

반응식

FC1C=C([C@@H]2CCCC(=O)N2[C:16]([O:18]C(C)(C)C)=[O:17])C=C(F)C=1.[F:23][C:24]1[CH:25]=[C:26]([C@H:31]2[N:36]([C:37](OC(C)(C)C)=O)[C:35](=[O:44])[C@H:34]([CH3:45])[CH2:33][CH2:32]2)[CH:27]=[C:28]([F:30])[CH:29]=1>>[F:30][C:28]1[CH:27]=[C:26]([C@H:31]2[N:36]([CH2:37][C:16]([OH:18])=[O:17])[C:35](=[O:44])[C@H:34]([CH3:45])[CH2:33][CH2:32]2)[CH:25]=[C:24]([F:23])[CH:29]=1

참가 물질

반응물 2

HCID 66865136HCID 66865136, 화합물

HCID 66973304HCID 66973304, 화합물

생성물 1

HCID 57974031HCID 57974031, 화합물

실험 절차

Essentially following the procedures described for Intermediate 26, but using tert-butyl (3R,6S)-6-(3,5-difluorophenyl)-3-methylpiperidin-2-one-1-carboxylate in place of tert-butyl (6S)-6-(3,5-difluorophenyl)-3,3-diethylpiperidin-2-one-1-carboxylate, the title compound was prepared. MS: m/z=284 (M+1).

출처 및 근거

ORD 기록: ord-e78c134d17604c65bd2a80926228de8e
출처 데이터셋: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07629338B2

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