3,4-Dichlorocinnamic acid → (Rac)-1-[(e)-3-(3,4-dichloro-phenyl)-acryloyl]-6-methyl-[1,4]diazepan-5-one

HRID 1867393

반응식

HRID 1867393 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][C:12]=1[Cl:13])/[CH:5]=[CH:6]/[C:7]([OH:9])=O.Cl.[CH3:15][CH:16]1[CH2:22][NH:21][CH2:20][CH2:19][NH:18][C:17]1=[O:23]>>[Cl:1][C:2]1[CH:3]=[C:4](/[CH:5]=[CH:6]/[C:7]([N:21]2[CH2:22][CH:16]([CH3:15])[C:17](=[O:23])[NH:18][CH2:19][CH2:20]2)=[O:9])[CH:10]=[CH:11][C:12]=1[Cl:13]

참가 물질

3

반응물 2

HCID 6880273,4-Dichlorocinnamic acidHCID 684349836-Methyl-1,4-diazepan-5-one hydrochloride

생성물 1

HCID 68432289(Rac)-1-[(e)-3-(3,4-dichloro-phenyl)-acryloyl]-6-methyl-[1,4]diazepan-5-one

실험 절차

In analogy to the procedure described in intermediate 78C, (E)-3,4-dichlorocinnamic acid and 6-methyl-[1,4]diazepan-5-one hydrochloride gave the title compound as a colorless gum, MS: 327.1 (MH+).

출처 및 근거

ORD 기록
ord-d5ecb3da94114dcea2c2af6b1d8127fb
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632829B2

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