1-(2-Chloroethyl)piperidine → 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-(2-piperidin-1-yl-ethyl)-[1,4]diazepan-5-one

HRID 1867401

반응식

HRID 1867401 반응식
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[NH:16][CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl[CH2:22][CH2:23][N:24]1[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[N:16]([CH2:22][CH2:23][N:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

3

반응물 2

HCID 748271-(2-Chloroethyl)piperidineHCID 620449211-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one2회

생성물 1

HCID 684323871-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-(2-piperidin-1-yl-ethyl)-[1,4]diazepan-5-one

실험 절차

In analogy to the procedure described in intermediate 4A, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 1A) and 1-(2-chloro-ethyl)-piperidine gave the title compound as white solid. MS: 424.1 (MH+, 2Cl).

출처 및 근거

ORD 기록
ord-2af552448bab4402adb04717ac842f6b
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632829B2

연결된 노트

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