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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1867407생성일: 2026년 10월 26일

2-(3-Bromopropoxy)tetrahydro-2H-pyran → 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-[3-(tetrahydro-pyran-2-yloxy)-propyl]-[1,4]diazepan-5-one

https://huagongshe.com/reaction/1867407

반응식

참여 물질

역할이름HCID투입량
반응물2-(3-Bromopropoxy)tetrahydro-2H-pyranHCID 2777988—
반응물1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-oneHCID 62044921—
생성물1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-[3-(tetrahydro-pyran-2-yloxy)-propyl]-[1,4]diazepan-5-oneHCID 68435254—

반응 단계

In analogy to the procedure described in example 5A, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 1A]) and 2-(3-bromo-propoxy)-tetrahydro-pyran gave the title compound as white solid. MS: 455.3 (MH+, 2Cl).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07632829B2
출처 데이터셋uspto-grants-2009_12
ORD IDord-dce800a603834be19375384a5461168c
출처 메모uspto-grants-2009_12