Methanesulfonyl chloride → HCID 86615869, 화합물

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[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[N:16]([CH2:21][CH2:22][CH2:23][OH:24])[CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8].[CH3:25][S:26](Cl)(=[O:28])=[O:27]>>[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[N:16]([CH2:21][CH2:22][CH2:23][O:24][S:26]([CH3:25])(=[O:28])=[O:27])[CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

반응물 2

HCID 31297Methanesulfonyl chloride

HCID 684344201-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-(3-hydroxy-propyl)-[1,4]diazepan-5-one

생성물 1

HCID 86615869HCID 86615869, 화합물

실험 절차

In analogy to the procedure described in example 5C, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-4-(3-hydroxy-propyl)-[1,4]diazepan-5-one and methanesulfonyl chloride gave the crude title compound as white foam and as a mixture of mainly mesylate and some chloride.

출처 및 근거

ORD 기록: ord-e54e00978ac34deeadd3fcb360e84fc6
출처 데이터셋: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07632829B2

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