1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one → 1-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-(2,2-dimethyl-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

HRID 1867445노트

반응식

HRID 1867445 반응식
[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[NH:16][CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8].I[CH2:22][C:23]([CH3:32])([CH3:31])[CH2:24][N:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[Cl:1][C:2]1[CH:3]=[C:4](/[CH:9]=[CH:10]/[C:11]([N:13]2[CH2:19][CH2:18][C:17](=[O:20])[N:16]([CH2:22][C:23]([CH3:32])([CH3:31])[CH2:24][N:25]3[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]3)[CH2:15][CH2:14]2)=[O:12])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

3

반응물 2

HCID 620449211-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one2회HCID 684347421-(3-Iodo-2,2-dimethyl-propyl)-piperidine

생성물 1

HCID 684344481-[(E)-3-(3,4-Dichloro-phenyl)-acryloyl]-4-(2,2-dimethyl-3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one

실험 절차

In analogy to the procedure described for intermediate 4A, 1-[(E)-3-(3,4-dichloro-phenyl)-acryloyl]-[1,4]diazepan-5-one (intermediate 1A]) and 1-(3-iodo-2,2-dimethyl-propyl)-piperidine stirred 2 h at RT, gave the title compound as white solid. MS: 466.3 (MH+, 2Cl).

출처 및 근거

ORD 기록
ord-6e3753ade0ff44bca06ffb3e6651e3a6
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632829B2

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