2-Chloroethyl isocyanate → HCID 68566485, 화합물

HRID 1867575노트

반응식

HRID 1867575 반응식
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[O:9])[CH2:4][CH2:3]1.[Cl:15][CH2:16][CH2:17]N=C=O>O1CCCC1>[C:11]([O:10][C:8]([N:5]1[CH2:4][CH2:3][CH:2]([NH:1][CH2:17][CH2:16][Cl:15])[CH2:7][CH2:6]1)=[O:9])([CH3:14])([CH3:13])[CH3:12]

참가 물질

4

반응물 2

HCID 160352-Chloroethyl isocyanateHCID 12682914-Amino-1-Boc-piperidine

생성물 1

HCID 68566485HCID 68566485, 화합물수율 116.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 4-amino-1-t-butoxycarbonylpiperidine (200 mg, 1.0 mmol) in tetrahydrofuran (5 mL) was treated with 2-chloroethyl isocyanate (0.090 mL, 1.0 mmol) overnight. The solvent was evaporated to provide the title compound as a white solid (305 mg).

후처리

  1. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-abf51cf21fe442d4938cbf3b8fb835b8
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632832B2

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