Trifluoroacetic acid → Trifluoroacetic acid

HRID 1867579노트

반응식

HRID 1867579 반응식
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(OC([N:15]1[CH2:20][CH2:19][CH:18]([N:21]2[CH2:25][CH2:24][NH:23][C:22]2=[O:26])[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[NH:15]1[CH2:16][CH2:17][CH:18]([N:21]2[CH2:25][CH2:24][CH2:2][NH:23][C:22]2=[O:26])[CH2:19][CH2:20]1.[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4]

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 46344059Tert-butyl 4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate

생성물 2

HCID 6422Trifluoroacetic acidHCID 155726661-(Piperidin-4-yl)-1,3-diazinan-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (0.5 mL) was added to a solution of 1-(1-t-butoxycarbonylpiperidin-4-yl)imidazolidin-2-one (20 mg, 0.07 mmol) in dichloromethane (2 mL) and the reaction stirred at room temperature overnight. The reaction was concentrated in vacuo to give the title compound as its trifluoroacetic acid salt (12 mg).

후처리

  1. concentrationThe reaction was concentrated in vacuo

출처 및 근거

ORD 기록
ord-5b9695d05f5d46c5aa4c11c558682937
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632832B2

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