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Trifluoroacetic acid → 4-(Hydroxymethyl)-1-piperidin-4-yl-1,3-dihydro-2H-imidazol-2-one

HRID 1867600
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인쇄 미리보기

반응식

HRID 1867600 반응식
FC(F)(F)C(O)=O.[Si]([O:25][CH2:26][C:27]1[NH:28][C:29](=[O:45])[N:30]([CH:32]2[CH2:37][CH2:36][N:35](C(OC(C)(C)C)=O)[CH2:34][CH2:33]2)[CH:31]=1)(C(C)(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>ClCCl>[OH:25][CH2:26][C:27]1[NH:28][C:29](=[O:45])[N:30]([CH:32]2[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]2)[CH:31]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 68567938tert-Butyl 4-[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]piperidine-1-carboxylate

생성물 1

HCID 579795704-(Hydroxymethyl)-1-piperidin-4-yl-1,3-dihydro-2H-imidazol-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Trifluoroacetic acid (5 mL) was added to a solution of tert-butyl 4-[4-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]piperidine-1-carboxylate (550 mg, 1.03 mmol) in dichloromethane (15 mL). After 30 min, the reaction was concentrated to give the title compound.

후처리

  1. concentrationthe reaction was concentrated

출처 및 근거

ORD 기록
ord-860197482a3a4d268622f80ca5077639
출처 데이터셋
uspto-grants-2009_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07632832B2

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