홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Water → N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl)-4-chloronicotinamide

HRID 1867653
노트
인쇄 미리보기

반응식

HRID 1867653 반응식
[Cl:1][C:2]1[C:3]([O:12][C:13]2[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][CH:14]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.C(N(CC)CC)C.Cl.[Cl:28][C:29]1[C:34]([C:35](Cl)=[O:36])=[CH:33][N:32]=[CH:31][CH:30]=1.O>O1CCCC1>[Cl:1][C:2]1[C:3]([O:12][C:13]2[CH:19]=[CH:18][C:16]([NH:17][C:35](=[O:36])[C:34]3[C:29]([Cl:28])=[CH:30][CH:31]=[N:32][CH:33]=3)=[CH:15][CH:14]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 27641164-{[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}anilineHCID 231520084-Chloronicotinoyl chloride hydrochloride

생성물 1

HCID 23151884N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl)-4-chloronicotinamide

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

A solution of 150 mg of 4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)aniline and 116 mg of triethylamine in 5 mL of tetrahydrofuran was stirred with 100 mg of 4-chloronicotinoyl chloride hydrochloride for about 50 minutes, and after addition of water, the precipitated crystals were recovered by filtration. The recovered crystals were washed with ether and dried to 106 mg of N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl)-4-chloronicotinamide having a melting point of 178-180° C. (decomposition).

후처리

  1. filtrationthe precipitated crystals were recovered by filtration
  2. washThe recovered crystals were washed with ether
  3. dry with materialdried to 106 mg of N-(4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl)-4-chloronicotinamide having a melting point of 178-180° C. (decomposition)

출처 및 근거

ORD 기록
ord-afe8394e47b649088fd1799f755c126a
출처 데이터셋
uspto-grants-2009_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07632865B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트