Methanesulfonyl chloride → N-(4-bromo-2-fluorophenyl)methanesulfonamide
반응식
[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([F:9])[CH:3]=1.[CH3:10][S:11](Cl)(=[O:13])=[O:12]>ClCCl.N1C=CC=CC=1>[Br:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][S:11]([CH3:10])(=[O:13])=[O:12])=[C:4]([F:9])[CH:3]=1참가 물질
4
실험 절차
Procedure MM: To a stirring solution of 4-bromo-2-fluoroaniline (1.0 mmol) in 3:1 dichloromethane/pyridine, add methanesulfonyl chloride (1.5 mmol) and stir at room temperature for 18 hours. After this time, wash the reaction with 1N hydrochloric acid while extracting with dichoromethane. Purify the title compound via radial chromatography eluting with ethyl acetate and hexane.
후처리
- washAfter this time, wash
- customthe reaction with 1N hydrochloric acid
- extractionwhile extracting with dichoromethane
- customPurify the title compound via radial chromatography
- washeluting with ethyl acetate and hexane
출처 및 근거
- ORD 기록
- ord-92e976a67c5a480188b2bf6350597e2c
- 출처 데이터셋
- uspto-grants-2009_12
- 특허 번호
- US07632857B2
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