(4-(Methylsulfinyl)phenyl)boronic acid → (3-Fluoro-4'-methanesulfinyl-biphenyl-4-yl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

HRID 1867836

반응식

HRID 1867836 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:14][CH2:13][CH2:12][C@H:11]2[CH2:15][N:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:9])=[C:4]([F:21])[CH:3]=1.[CH3:22][S:23]([C:25]1[CH:30]=[CH:29][C:28](B(O)O)=[CH:27][CH:26]=1)=[O:24]>>[F:21][C:4]1[CH:3]=[C:2]([C:28]2[CH:29]=[CH:30][C:25]([S:23]([CH3:22])=[O:24])=[CH:26][CH:27]=2)[CH:7]=[CH:6][C:5]=1[C:8]([N:10]1[CH2:14][CH2:13][CH2:12][C@H:11]1[CH2:15][N:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1)=[O:9]

참가 물질

3

반응물 2

HCID 2773531(4-(Methylsulfinyl)phenyl)boronic acidHCID 11965125(4-Bromo-2-fluoro-phenyl)-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

생성물 1

HCID 57980145(3-Fluoro-4'-methanesulfinyl-biphenyl-4-yl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone

실험 절차

The title compound is prepared in a manner substantially analogous to Procedure SS starting from (4-bromo-2-fluoro-phenyl)-(2-(S)-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone and 4-Methylsulfinyl benzene boronic acid. MS (M+H) 415.1

출처 및 근거

ORD 기록
ord-3ca7ad54580b4f07bb19f0070e6e7030
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632857B2

연결된 노트

불러오는 중…