Phenylacetic Acid → N'-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)-2-phenylacetohydrazide

HRID 1867876

반응식

HRID 1867876 반응식
C1(CC(O)=O)C=CC=CC=1.[Cl:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]1[N:23]=[N:22][C:21]([NH:24][NH:25][C:26](=[O:34])[CH2:27][CH:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[CH:20][C:19]=1[C:35]1[CH:40]=[CH:39][C:38]([Cl:41])=[CH:37][CH:36]=1>>[Cl:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:18]1[N:23]=[N:22][C:21]([NH:24][NH:25][C:26](=[O:34])[CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:20][C:19]=1[C:35]1[CH:36]=[CH:37][C:38]([Cl:41])=[CH:39][CH:40]=1

참가 물질

3

반응물 2

HCID 999Phenylacetic AcidHCID 57979752N'-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)-2-cyclohexylacetohydrazide

생성물 1

HCID 57979739N'-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)-2-phenylacetohydrazide수율 47%

실험 절차

The title compound (42 mg, 47%) as a white foam was prepared from 2-phenylacetic acid (41 mg, 0.3 mmol) and 1-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3)hydrazine (66 mg, 0.2 mmol) according to the procedures described for N′-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)-2-cyclohexylacetohydrazide (Example 7A). HPLC/MS (method A): retention time =3.30 min, (M+H)+=449.2.

후처리

  1. customretention time =3.30 min, (M+H)+=449.2

출처 및 근거

ORD 기록
ord-44260eb49b47412380db6d9c2e723457
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632837B2

연결된 노트

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