Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-(2-Chlorophenyl)-7-(4-chlorophenyl)-3-(cyclohexylmethyl)-[1,2,4]triazolo[4,3-b]pyridazine → 3-Benzyl-6-(2-chlorophenyl)-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-(2-Chlorophenyl)-7-(4-chlorophenyl)-3-(cyclohexylmethyl)-[1,2,4]triazolo[4,3-b]pyridazine | HCID 11993108 | — |
| 반응물 | Triphenylphosphane dichloride | HCID 13797396 | — |
| 반응물 | N'-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)-2-phenylacetohydrazide | HCID 57979739 | — |
| 생성물 | 3-Benzyl-6-(2-chlorophenyl)-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine | HCID 11993109 | 54.6% |
반응 단계
The title compound (20 mg, 54%) as a white powder was prepared from N′-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)-2-phenylacetohydrazide (38 mg, 0.085 mmol) and triphenylphosphine dichloride (85 mg, 0.26 mmol) according to the procedures described for 6-(2-chlorophenyl)-7-(4-chlorophenyl)-3-(cyclohexylmethyl)-[1,2,4]triazolo[4,3-b]pyridazine (Example 7B). HPLC/MS (method A): retention time=3.92 min, (M+H)+=431.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07632837B2 |
| 출처 데이터셋 | uspto-grants-2009_12 |
| ORD ID | ord-0de0e1b568fc4027a6c63b2e9479ae13 |
| 출처 메모 | uspto-grants-2009_12 |