Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-(2-Chlorophenyl)-7-(4-chlorophenyl)-3-(cyclohexylmethyl)-[1,2,4]triazolo[4,3-b]pyridazine → 3-(4-Chlorobenzyl)-6-(2-chlorophenyl)-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-(2-Chlorophenyl)-7-(4-chlorophenyl)-3-(cyclohexylmethyl)-[1,2,4]triazolo[4,3-b]pyridazine | HCID 11993108 | — |
| 반응물 | Triphenylphosphane dichloride | HCID 13797396 | — |
| 반응물 | 2-(4-chlorophenyl)-N'-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)acetohydrazide | HCID 57979753 | — |
| 생성물 | 3-(4-Chlorobenzyl)-6-(2-chlorophenyl)-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazine | HCID 11993111 | 54% |
반응 단계
The title compound (50 mg, 54%) as a white powder was prepared from 2-(4-chlorophenyl)-N′-(6-(2-chlorophenyl)-5-(4-chlorophenyl)pyridazin-3-yl)acetohydrazide (96 mg, 0.2 mmol) and triphenylphosphine dichloride (220 mg,0.66 mmol) according to the procedures described for 6-(2-chlorophenyl)-7-(4-chlorophenyl)-3-(cyclohexylmethyl)-[1,2,4]triazolo[4,3-b]pyridazine (Example 7B). HPLC/MS (method A): retention time=4.12 min, (M+H)+=465.2.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07632837B2 |
| 출처 데이터셋 | uspto-grants-2009_12 |
| ORD ID | ord-d397fa5ec9954711bf8041bf622dbb4d |
| 출처 메모 | uspto-grants-2009_12 |