Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1-Dichloroethane → 1-(3-Chloropyridin-2-yl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1-Dichloroethane | HCID 6365 | — |
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate | HCID 11630777 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-(3-Chloropyridin-2-yl)piperazine | HCID 11412944 | — |
반응 단계
To a clear solution of tert-butyl 4-(3-chloropyridin-2-yl)piperazine-1-carboxylate in anhydrous dichloromethane (25 mL) was added TFA (25 mL) dropwise. The yellow solution was stirred at room temperature for 2.5 hour. Reaction was complete as determined by TLC. TFA was azeotropped with dichloroethane to give 1-(3-chloropyridin-2-yl)piperazine in quantitative yield (1.265 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07632838B2 |
| 출처 데이터셋 | uspto-grants-2009_12 |
| ORD ID | ord-30b29d4f567642f38fcd9d67ddf87c72 |
| 출처 메모 | uspto-grants-2009_12 |