Isoquinoline, 1-chloro- → 1-[4-(2-Naphthylsulfonyl)piperidin-1-yl]isoquinoline

HRID 1868045노트

반응식

HRID 1868045 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)(=[O:13])=[O:12].Cl[C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][N:22]=1>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([CH:14]1[CH2:19][CH2:18][N:17]([C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH:24]=[CH:23][N:22]=2)[CH2:16][CH2:15]1)(=[O:12])=[O:13]

참가 물질

3

반응물 2

HCID 140539Isoquinoline, 1-chloro-HCID 227219374-(2-Naphthylsulfonyl)piperidine

생성물 1

HCID 685541961-[4-(2-Naphthylsulfonyl)piperidin-1-yl]isoquinoline수율 73.6%

실험 절차

Using the procedure from Example 7A, Step 7E, 4-(2-naphthylsulfonyl)piperidine (130 mg, 0.51 mmol) was reacted with 1-chloroisoquinoline (164 mg, 1.0 mmol) to afford the title compound (151 mg), a white solid, in 31% yield.

출처 및 근거

ORD 기록
ord-c739d2f1c98d4db3b3a8507e4ce9f083
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07632838B2

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