Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Norborn-2-ylacetic acid → 1-(Bicyclo[2.2.1]hept-2-ylacetyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Norborn-2-ylacetic acid | HCID 79139 | — |
| 반응물 | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| 반응물 | 1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine | HCID 2777786 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(Bicyclo[2.2.1]hept-2-ylacetyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine | HCID 68552149 | 82% |
반응 단계
Coupling of 1-(3-(trifluoromethyl)pyridin-2-yl)piperazine (271 mg, 1.17 mmol) with 2-(bicyclo[2.2.1]heptan-2-yl)acetic acid (100 mg, 0.65 mmol) was carried out according to a similar procedure described for example 19A using N,N-dimethylformamide (1 mL) as solvent and benzotriazole-1 yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate (700 mg, 1.56 mmol) as coupling agent. 1-(bicyclo[2.2.1]hept-2-ylacetyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine was obtained in 82% yield (195 mg) as colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07632838B2 |
| 출처 데이터셋 | uspto-grants-2009_12 |
| ORD ID | ord-7f6132978a0347089cab39391db43e51 |
| 출처 메모 | uspto-grants-2009_12 |