Cyclopropanemethanamine → HCID 57982658, 화합물

HRID 1868390노트

반응식

HRID 1868390 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[N:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[C:13]([C:20]([OH:22])=O)=[CH:12][N:11]=1.[CH:23]1([CH2:26][NH2:27])[CH2:25][CH2:24]1>>[CH:23]1([CH2:26][NH:27][C:20]([C:13]2[C:14]([C:16]([F:19])([F:18])[F:17])=[N:15][C:10]([NH:9][C:3]3[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=3[Cl:1])=[N:11][CH:12]=2)=[O:22])[CH2:25][CH2:24]1

참가 물질

3

반응물 2

HCID 75646CyclopropanemethanamineHCID 167197432-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid

생성물 1

HCID 57982658HCID 57982658, 화합물수율 63%

실험 절차

In a manner similar to Reference Example 1 (c) 2-(2,4-dichlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (80 mg) and cyclopropylmethylamine (19 mg, ex Lancaster) afforded the title compound (58 mg).

출처 및 근거

ORD 기록
ord-2eccd4570dfd4e79a176028d573e8ac1
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07635701B2

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