2-(Phenylamino)-4-(trifluoromethyl)pyrimidine-5-carboxylic acid → 2-(Phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide

HRID 1868398노트

반응식

HRID 1868398 반응식
[C:1]1([NH:7][C:8]2[N:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[C:11]([C:18]([OH:20])=O)=[CH:10][N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH:22]1([CH2:27][NH2:28])[CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH:22]1([CH2:27][NH:28][C:18]([C:11]2[C:12]([C:14]([F:15])([F:16])[F:17])=[N:13][C:8]([NH:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[N:9][CH:10]=2)=[O:20])[CH2:26][CH2:25][CH2:24][CH2:23]1

참가 물질

3

반응물 2

HCID 167195502-(Phenylamino)-4-(trifluoromethyl)pyrimidine-5-carboxylic acidHCID 18784136Cyclopentylmethanamine hydrochloride

생성물 1

HCID 579826782-(Phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopentylmethyl-amide수율 82.9%

실험 절차

In a manner similar to Reference Example 1 (c), 2-(Phenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (30 mg) and cyclopentylmethylamine hydrochloride (21 mg) afforded the title compound (32 mg) after purification by trituration with diethylether.

출처 및 근거

ORD 기록
ord-a1cdb7b6234b4ae399a9a356e86a951a
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07635701B2

반응 노트

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