HCID 67099598, 화합물 → HCID 57983572, 화합물

HRID 1868690노트

반응식

HRID 1868690 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]1([CH2:15][CH2:14][CH2:13][CH2:12]1)[C:7](=[O:16])[C:6]([C:17]([NH:19][CH2:20][C:21]([O:23]C(C)(C)C)=[O:22])=[O:18])=[C:5]2[OH:28]>C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]1([CH2:12][CH2:13][CH2:14][CH2:15]1)[C:7](=[O:16])[C:6]([C:17]([NH:19][CH2:20][C:21]([OH:23])=[O:22])=[O:18])=[C:5]2[OH:28]

참가 물질

3

반응물 1

HCID 67099598HCID 67099598, 화합물

생성물 1

HCID 57983572HCID 57983572, 화합물수율 77.2%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

A mixture of 1,1-dimethylethyl N-((6′-chloro-4′-hydroxy-2′-oxo-2′H-spiro[cyclopentane-1,1′-naphthalen]-3′-yl)carbonyl)glycinate (0.2 g, 0.5 mmol) in 2 mL TFA was stirred at room temperature for 30 minutes, M+1=350. The mixture was concentrated and triturated in ether/hexane (10:1). The solid was filtered, washed with 10 mL ether/hexane (10:1), and dried under high vacuum to give 135 mg of the salt as an off-white solid. MS (m/z)=350 (M+H)+. Calculated for C17H16ClNO5 349.07.

후처리

  1. concentrationThe mixture was concentrated
  2. customtriturated in ether/hexane (10:1)
  3. filtrationThe solid was filtered
  4. washwashed with 10 mL ether/hexane (10:1)
  5. customdried under high vacuum

출처 및 근거

ORD 기록
ord-4075eb8dba854e36a2a7fa93518ab9d4
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07635715B2

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