Thionyl Chloride → HCID 86629256, 화합물

HRID 1868691노트

반응식

HRID 1868691 반응식
[I:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:17])=O>>[I:1][C:2]1[C:10]([C:11]([F:14])([F:13])[F:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:17])=[O:5]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 146125442-Iodo-3-(trifluoromethyl)benzoic acid

생성물 1

HCID 86629256HCID 86629256, 화합물수율 99.4%

실험 절차

2-Iodo-3-(trifluoromethyl)benzoic acid (10.0 g, 31.6 mmol) was stirred in thionyl chloride (100 mL, 31.6 mmol) at reflux for 2 hours. The mixture was then cooled to room temperature. The thionyl chloride was removed under vacuum, and the residue was azeotroped with dry toluene to give the product as a yellow-orange semi-solid (10.51 g).

후처리

  1. temperatureat reflux for 2 hours
  2. customThe thionyl chloride was removed under vacuum
  3. customthe residue was azeotroped with dry toluene

출처 및 근거

ORD 기록
ord-b6b13cc96d224ffeb2f1caa5ab767cb8
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07635715B2

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