HCID 67100256, 화합물 → HCID 57983375, 화합물

HRID 1868805노트

반응식

HRID 1868805 반응식
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[CH:10]=2)[C:5]2([CH2:21][CH2:20][CH2:19][CH2:18]2)[C:4](=[O:22])[C:3]=1[C:23]([NH:25][CH2:26][C:27]([O:29]C(C)(C)C)=[O:28])=[O:24]>C(O)(C(F)(F)F)=O.CCOCC>[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:10]=2)[C:5]2([CH2:21][CH2:20][CH2:19][CH2:18]2)[C:4](=[O:22])[C:3]=1[C:23]([NH:25][CH2:26][C:27]([OH:29])=[O:28])=[O:24]

참가 물질

4

반응물 1

HCID 67100256HCID 67100256, 화합물

생성물 1

HCID 57983375HCID 57983375, 화합물수율 20.9%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 6422Trifluoroacetic acid용매

실험 절차

1,1-Dimethylethyl N-((4′-hydroxy-2′-oxo-6′-phenyl-spiro[cyclopentane-1,1′-naphthalen]-3′-yl)carbonyl)glycinate (115 mg, 257 μmol) was dissolved in TFA (2 mL) at ambient temperature. The reaction was stirred for 30 minutes and was then concentrated to give an oil, dissolved in ether, concentrated again to give an amorphous solid, precipitated with ether, filtered, washed with ether, and dried in a vacuum oven to give the title compound (21 mg) as a white solid. MS (m/z)=392 (M+H)+. Calculated for the C23H21NO5 391.14.

후처리

  1. concentrationwas then concentrated
  2. customto give an oil
  3. concentrationconcentrated again
  4. customto give an amorphous solid
  5. customprecipitated with ether
  6. filtrationfiltered
  7. washwashed with ether
  8. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-d1de8b80a5274a2d9e9f7b388625b10e
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07635715B2

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