Triethylamine → 3,3-dichloro-N-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propyl}-2-(4-trifluoromethyl-phenyl)-acrylamide

HRID 1869139노트

반응식

HRID 1869139 반응식
[Cl:1][C:2]([Cl:17])=[C:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1)[C:4]([OH:6])=O.O=C1N(P(Cl)(N2CCOC2=O)=O)CCO1.C(N(CC)CC)C.[Cl:40][C:41]1[CH:51]=[C:50]([O:52][CH2:53][CH:54]=[C:55]([Cl:57])[Cl:56])[CH:49]=[C:48]([Cl:58])[C:42]=1[O:43][CH2:44][CH2:45][CH2:46][NH2:47]>ClCCl.C(OCC)(=O)C>[Cl:17][C:2]([Cl:1])=[C:3]([C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1)[C:4]([NH:47][CH2:46][CH2:45][CH2:44][O:43][C:42]1[C:48]([Cl:58])=[CH:49][C:50]([O:52][CH2:53][CH:54]=[C:55]([Cl:57])[Cl:56])=[CH:51][C:41]=1[Cl:40])=[O:6]

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 152842Bis(2-oxo-3-oxazolidinyl)phosphinic chlorideHCID 158697443-[2,6-Dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propylamineHCID 866130803,3-Dichloro-2-(4-trifluoromethyl-phenyl)-acrylic acid

생성물 1

HCID 112964533,3-dichloro-N-{3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propyl}-2-(4-trifluoromethyl-phenyl)-acrylamide

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

74 mg of 3,3-dichloro-2-(4-trifluoromethyl-phenyl)-acrylic acid, 67 mg of bis(2-oxo-3-oxazolidinyl)-phosphinic acid chloride, 53 mg of triethylamine and 100 mg of 3-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-propylamine are stirred in 2 ml of dichloromethane for 48 hours at 40° C. The reaction mixture is diluted with 16 ml of ethyl acetate and washed twice with aqueous potassium carbonate solution. After concentration of the organic phase and purification over silica gel, the title compound is obtained.

후처리

  1. washwashed twice with aqueous potassium carbonate solution
  2. customAfter concentration of the organic phase and purification over silica gel

출처 및 근거

ORD 기록
ord-a20d22ad4fe74cfda6fd3bc395557689
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07638514B2

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