Potassium tert-butoxide → 1,3-Dichloro-5-(3,3-dichloro-allyloxy)-2-[2-(4-trifluoromethyl-phenoxymethyl)-allyloxy]-benzene

HRID 1869143노트

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HRID 1869143 반응식
[CH3:1]C([O-])(C)C.[K+].[Cl:7][C:8]1[CH:29]=[C:28]([O:30][CH2:31][CH:32]=[C:33]([Cl:35])[Cl:34])[CH:27]=[C:26]([Cl:36])[C:9]=1[O:10][CH2:11][C:12](=O)[CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=1>[Br-].C[P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.C1(C)C=CC=CC=1>[Cl:7][C:8]1[CH:29]=[C:28]([O:30][CH2:31][CH:32]=[C:33]([Cl:34])[Cl:35])[CH:27]=[C:26]([Cl:36])[C:9]=1[O:10][CH2:11][C:12]([CH2:13][O:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:24])[F:23])=[CH:17][CH:16]=1)=[CH2:1]

참가 물질

5

반응물 2

HCID 23665647Potassium tert-butoxideHCID 86613082HCID 86613082, 화합물

생성물 1

HCID 866130831,3-Dichloro-5-(3,3-dichloro-allyloxy)-2-[2-(4-trifluoromethyl-phenoxymethyl)-allyloxy]-benzene

시약·촉매·용매 2

HCID 74505Methyltriphenyliphosphonium bromide촉매HCID 1140Toluene용매2회

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온도
50 °C

실험 절차

189 mg of potassium tert-butylate and 532 mg of methyltriphenylphosphonium bromide are heated in 8 ml of toluene for 3 hours at 80° C. The reaction mixture is cooled to 50° C. and a solution of 500 mg of 1-[2,6-dichloro-4-(3,3-dichloro-allyloxy)-phenoxy]-3-(4-tri-fluoromethyl-phenoxy)-propan-2-one in 5 ml of toluene is added in the course of 5 minutes. After 2 hours at 80° C., the reaction mixture is filtered, diluted with ethyl acetate and washed with water. After concentration of the organic phase and purification over silica gel, the title compound is obtained.

후처리

  1. filtrationthe reaction mixture is filtered
  2. additiondiluted with ethyl acetate
  3. washwashed with water
  4. customAfter concentration of the organic phase and purification over silica gel

출처 및 근거

ORD 기록
ord-9b272468c2e541609d40f113bdd2af65
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07638514B2

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