홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Bicarbonate → 1-[(2-Methylquinolin-5-yl)amino]-4,4-dimethyl-2-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-2-ol

HRID 1869355
노트
인쇄 미리보기

반응식

HRID 1869355 반응식
[F:1][C:2]([F:29])([F:28])[C:3]([CH:15]=[N:16][C:17]1[CH:26]=[CH:25][CH:24]=[C:23]2[C:18]=1[CH:19]=[CH:20][C:21]([CH3:27])=[N:22]2)([OH:14])[CH2:4][C:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)([CH3:7])[CH3:6].C([O-])(O)=O.[Na+]>C(Cl)Cl.[Ti](Cl)(Cl)(Cl)Cl.C(Cl)Cl>[CH3:27][C:21]1[CH:20]=[CH:19][C:18]2[C:23](=[CH:24][CH:25]=[CH:26][C:17]=2[NH:16][CH:15]2[C:9]3[C:8](=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:5]([CH3:6])([CH3:7])[CH2:4][C:3]2([C:2]([F:1])([F:28])[F:29])[OH:14])[N:22]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 2

HCID 516892Sodium BicarbonateHCID 179891651,1,1-Trifluoro-4-phenyl-2-[(2-methylquinolin-5-yl)iminomethyl]-4-methylpentan-2-ol

생성물 1

HCID 686823591-[(2-Methylquinolin-5-yl)amino]-4,4-dimethyl-2-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalen-2-ol수율 84.7%

시약·촉매·용매 2

HCID 57473882titanium tetrachloride CH2Cl2촉매
HCID 6344
Dichloromethane
용매

실험 절차

5.1 ml of a 1 M titanium tetrachloride-CH2Cl2 solution is added in drops to a solution of 111 mg of 1,1,1-trifluoro-4-phenyl-2-[(2-methylquinolin-5-yl)iminomethyl]-4-methylpentan-2-ol in 84 ml of CH2Cl2 at −78° C. After 1 hour at −78° C., the batch is mixed with saturated NaHCO3 and heated to room temperature. The phases are separated, the aqueous phase is extracted with CH2Cl2, the combined organic phases are dried (Na2SO4) and concentrated by evaporation in a vacuum. Column chromatography on silica gel with cyclohexane-ethyl acetate yields 94 mg of product.

후처리

  1. customThe phases are separated
  2. extractionthe aqueous phase is extracted with CH2Cl2
  3. dry with materialthe combined organic phases are dried (Na2SO4)
  4. concentrationconcentrated by evaporation in a vacuum

출처 및 근거

ORD 기록
ord-84b9ecc1dea2467d8bab6f6382b36d9d
출처 데이터셋
uspto-grants-2009_12
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07638515B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트