Methanol → 5-Methyl-1H-indazol-4-amine

HRID 1869404노트

반응식

HRID 1869404 반응식
Cl[C:2]1[C:3]([NH2:11])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2.[CH3:12]O>[Pd]>[CH3:12][C:2]1[C:3]([NH2:11])=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][N:6]=[CH:5]2

참가 물질

4

반응물 2

HCID 887MethanolHCID 179892615-Chloro-1H-indazol-4-amine

생성물 1

HCID 193544325-Methyl-1H-indazol-4-amine수율 6%

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

Analogously to the production of 5-chloro-1H-indazol-4-ylamine, the regioisomeric mixture of the previous reaction (1.0 g, 5.64 mmol)) is reacted with 100 mg of palladium on carbon in methanol under hydrogen atmosphere for 16 hours at room temperature. After purification on silica gel with hexane/ethyl acetate (33% hexane, then 100% ethyl acetate), 53 mg (6% of theory) of 5-methyl-1H-indazol-4-ylamine is obtained.

후처리

  1. customAfter purification on silica gel with hexane/ethyl acetate (33% hexane

출처 및 근거

ORD 기록
ord-f0cce4393a6640e1a4afcd8e29369f38
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07638515B2

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