1,1-Dimethylethyl 4-[(1-ethyl-4-piperidinyl)methyl]-1-piperidinecarboxylate → 1-Ethyl-4-(piperidin-4-ylmethyl)piperidine

HRID 1869626노트

반응식

HRID 1869626 반응식
[CH2:1]([N:3]1[CH2:8][CH2:7][CH:6]([CH2:9][CH:10]2[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[CH2:5][CH2:4]1)[CH3:2]>Cl.O1CCOCC1>[CH2:1]([N:3]1[CH2:4][CH2:5][CH:6]([CH2:9][CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH2:7][CH2:8]1)[CH3:2]

참가 물질

3

반응물 1

HCID 688869521,1-Dimethylethyl 4-[(1-ethyl-4-piperidinyl)methyl]-1-piperidinecarboxylate

생성물 1

HCID 534072191-Ethyl-4-(piperidin-4-ylmethyl)piperidine수율 87.4%

시약·촉매·용매 1

HCID 204431481,4-Dioxane hydrochloride용매

실험 절차

1,1-Dimethylethyl 4-[(1-ethyl-4-piperidinyl)methyl]-1-piperidinecarboxylate (may be prepared as described in Description 7) (2.5 g) was stirred in a solution of HCl-Dioxane (70 ml, 4M) for 2 h. The solvent was evaporated and the resultant hydrochloride salt was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into DCM (3×50 ml) and the combined organics dried (MgSO4) and evaporated to give the title compound (D8) (1.48 g).

후처리

  1. customThe solvent was evaporated
  2. dissolutionthe resultant hydrochloride salt was dissolved in saturated potassium carbonate (25 ml)
  3. extractionThe solution was extracted into DCM (3×50 ml)
  4. dry with materialthe combined organics dried (MgSO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-5f11804044cf414b8dd5924d975cae79
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07638631B2

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