1,1-Dimethylethyl 4-{[1-(cyclopropylmethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate → 1-(Cyclopropylmethyl)-4-(4-piperidinylmethyl)piperidine

HRID 1869628노트

반응식

HRID 1869628 반응식
[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([CH2:11][CH:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[CH2:7][CH2:6]2)[CH2:3][CH2:2]1>Cl.O1CCOCC1>[CH:1]1([CH2:4][N:5]2[CH2:10][CH2:9][CH:8]([CH2:11][CH:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[CH2:7][CH2:6]2)[CH2:2][CH2:3]1

참가 물질

3

반응물 1

HCID 688855731,1-Dimethylethyl 4-{[1-(cyclopropylmethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate

생성물 1

HCID 688844871-(Cyclopropylmethyl)-4-(4-piperidinylmethyl)piperidine수율 71.2%

시약·촉매·용매 1

HCID 204431481,4-Dioxane hydrochloride용매

실험 절차

1,1-Dimethylethyl 4-{[1-(cyclopropylmethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate (may be prepared as described in Description 9) (2.0 g) was stirred in a solution of HCl-Dioxane (700 ml, 4M) for 2 h. The solvent was evaporated and the resultant yellow solid was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into dichloromethane (3×50 ml) and the combined organics dried (MgSO4) and evaporated to give the title compound (D10) (1.0 g).

후처리

  1. customThe solvent was evaporated
  2. dissolutionthe resultant yellow solid was dissolved in saturated potassium carbonate (25 ml)
  3. extractionThe solution was extracted into dichloromethane (3×50 ml)
  4. dry with materialthe combined organics dried (MgSO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-d559086f863143e38ba2ee3ddb87f8ba
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07638631B2

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