1,1-Dimethylethyl 4-{[1-(1-methylethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate → 1-Methyl-4-(4-piperidinylmethyl)piperidine

HRID 1869632노트

반응식

HRID 1869632 반응식
C[CH:2]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)[CH2:6][CH2:5]1)C>Cl.O1CCOCC1>[CH3:2][N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[CH2:6][CH2:5]1

참가 물질

3

반응물 1

HCID 688888451,1-Dimethylethyl 4-{[1-(1-methylethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate

생성물 1

HCID 534072351-Methyl-4-(4-piperidinylmethyl)piperidine수율 35.1%

시약·촉매·용매 1

HCID 204431481,4-Dioxane hydrochloride용매

실험 절차

1,1-Dimethylethyl 4-{[1-(1-methylethyl)-4-piperidinyl]methyl}-1-piperidinecarboxylate (may be prepared as described in Description 3) (3.1 g) was stirred in a solution of HCl-Dioxane (50 ml, 4M) for 2 h. The solvent was evaporated and the product was dissolved in saturated potassium carbonate (25 ml). The solution was extracted into dichloromethane (3×50 ml) and the combined organics dried (Na2SO4) and evaporated to give the title compound (D19) (0.658 g).

후처리

  1. customThe solvent was evaporated
  2. dissolutionthe product was dissolved in saturated potassium carbonate (25 ml)
  3. extractionThe solution was extracted into dichloromethane (3×50 ml)
  4. dry with materialthe combined organics dried (Na2SO4)
  5. customevaporated

출처 및 근거

ORD 기록
ord-8c6b9b13e72e45838b83f2b63b23aba9
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07638631B2

반응 노트

불러오는 중…