Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Methyl 2-[(2,6-dichlorobenzyl)amino]-3-(4-nitrophenyl)propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Bromomethyl-2,6-dichlorobenzene | HCID 30159 | — |
| 반응물 | Methyl 2-amino-3-(4-nitrophenyl)propanoate | HCID 560520 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Methyl 2-[(2,6-dichlorobenzyl)amino]-3-(4-nitrophenyl)propanoate | HCID 11269078 | — |
반응 단계
To a solution of methyl 2-amino-3-(4-nitrophenyl)propanoate 2 (6 g) in CH3CN (30 ml) is added, pulverized K2CO3 (11.095 g), 2,6-dichlorobenzyl bromide (6.42 g). The mixture is stirred at RT for 6 h then filtrated on decalite and evaporated. The residue is placed in CH2Cl2 (100 ml) and washed three time with water (100 ml) dried over MgSO4 and evaporated. The residue is purified by silica gel chromatography using AcOEt/hexane 10/90 as eluent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07638630B2 |
| 출처 데이터셋 | uspto-grants-2009_12 |
| ORD ID | ord-77af4de373604e2a9cb8fa413103c2c6 |
| 출처 메모 | uspto-grants-2009_12 |