Diethyl Ether → (3-Bromo-phenyl)-cyclopropyl-methyl-amine

HRID 1869955노트

반응식

HRID 1869955 반응식
[Br:1][C:2]1[CH:3]=[C:4]([N:8]([CH3:11])[CH:9]=O)[CH:5]=[CH:6][CH:7]=1.[CH2:12]([Mg]Br)[CH3:13].CCOCC.C(OCC)(=O)C>O1CCCC1.CCCCCC>[Br:1][C:2]1[CH:3]=[C:4]([N:8]([CH:9]2[CH2:13][CH2:12]2)[CH3:11])[CH:5]=[CH:6][CH:7]=1

참가 물질

7

반응물 4

HCID 3283Diethyl EtherHCID 8857Ethyl AcetateHCID 12030886N-(3-Bromo-phenyl)-N-methyl-formamide2회HCID 178418443HCID 178418443, 화합물

생성물 1

HCID 21107154(3-Bromo-phenyl)-cyclopropyl-methyl-amine수율 15%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8058Hexane용매

실험 절차

A stirred, cooled (0° C.) solution of N-(3-bromo-phenyl)-N-methyl-formamide (Intermediate 112, 2.6 g, 9.7 mmol) and titanium tetra-iso-propoxide (3.9 mL, 10.67 mmol) in tetrahydrofuran (40 mL) was treated with a 3M solution of ethyl magnesium bromide in ether (8.08 mL, 24.25 mmol) under argon and the resulting reaction mixture was allowed to warm to ambient temperature gradually and refluxed at 55° C. overnight. It was then cooled in an ice-bath, quenched with saturated aqueous ammonium chloride solution, filtered over celite and the aqueous phase was extracted with diethyl ether. The organic phase was dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford an oil. Flash column chromatography over silica gel (230-400 mesh) using 1.5% ethyl acetate in hexane as the eluent afforded the title compound (0.321 g, 15%).

후처리

  1. customthe resulting reaction mixture
  2. temperaturerefluxed at 55° C. overnight
  3. temperatureIt was then cooled in an ice-bath
  4. customquenched with saturated aqueous ammonium chloride solution
  5. filtrationfiltered over celite
  6. extractionthe aqueous phase was extracted with diethyl ether
  7. dry with materialThe organic phase was dried over anhydrous magnesium sulfate
  8. filtrationfiltered
  9. customevaporated in vacuo
  10. customto afford an oil

출처 및 근거

ORD 기록
ord-2110cc51edd64c989a6295443218b353
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07638648B2

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