Potassium Carbonate → HCID 57424255, 화합물

HRID 1869963노트

반응식

HRID 1869963 반응식
[CH:1]([O:4][C:5](=[O:24])[C:6]1[CH:11]=[CH:10][C:9]([C:12]#[C:13][Si](C)(C)C)=[CH:8][C:7]=1[CH2:18][N:19]([CH:21]1[CH2:23][CH2:22]1)[CH3:20])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[CH:1]([O:4][C:5](=[O:24])[C:6]1[CH:11]=[CH:10][C:9]([C:12]#[CH:13])=[CH:8][C:7]=1[CH2:18][N:19]([CH:21]1[CH2:23][CH2:22]1)[CH3:20])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 11430Potassium CarbonateHCID 69076270HCID 69076270, 화합물2회

생성물 1

HCID 57424255HCID 57424255, 화합물수율 78%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution 2-[(cyclopropyl-methyl-amino)-methyl]-4-trimethylsilanylethynyl-benzoic acid isopropyl ester (Intermediate 121, 0.34 g, 1 mmol) in methanol (2 mL) was treated with potassium carbonate (0.207 g, 1.5 mmol) and the resulting reaction mixture was stirred at ambient temperature for 4 h. The volatiles were evaporated in vacuo, the residue was diluted with water and extracted with diethyl ether, dried over anhydrous magnesium sulfate, filtered and evaporated in vacuo to afford the title compound as an oil (0.21 g, 78%).

후처리

  1. customthe resulting reaction mixture
  2. customThe volatiles were evaporated in vacuo
  3. additionthe residue was diluted with water
  4. extractionextracted with diethyl ether
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationfiltered
  7. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-6011a8875da54b68834b45ebb58517b5
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07638648B2

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