Sulfuric Acid → HCID 608316, 화합물
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=[O:6].S(=O)(=O)(O)O.[CH:16](O)([CH3:18])[CH3:17]>O>[CH:16]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][CH:10]=[C:2]([Br:1])[CH:3]=1)([CH3:18])[CH3:17]참가 물질
5
실험 절차
A solution of 3-bromo benzoic acid (Aldrich, 2.4 g, 11.9 mmol) in isopropanol (20 mL) was treated with 1 mL of concentrated sulfuric acid and the resulting reaction mixture was refluxed overnight. The reaction mixture was then cooled to ambient temperature and diluted with water and extracted with diethyl ether. The organic phase was dried over anhydrous sodium sulfate, filtered and evaporated to an oil that was subjected to flash column chromatography over silica gel (230-400 mesh) using 10% ethyl acetate in hexane as the eluent to afford the title compound as an oil (2.54 g, 88%).
후처리
- customthe resulting reaction mixture
- temperaturewas refluxed overnight
- extractionextracted with diethyl ether
- dry with materialThe organic phase was dried over anhydrous sodium sulfate
- filtrationfiltered
- customevaporated to an oil that
출처 및 근거
- ORD 기록
- ord-02738807d9c140879264d979d9867ab4
- 출처 데이터셋
- uspto-grants-2009_12
- 특허 번호
- US07638648B2
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