3-(2-(N-t-Butoxycarbonylamino)ethoxy)-5-chloro-1,2-benzisoxazole → 3-(2-Aminoethoxy)-5-chloro-1,2-benzisoxazole hydrochloride

반응식

C(OC([NH:8][CH2:9][CH2:10][O:11][C:12]1[C:16]2[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1)=O)(C)(C)C.Cl.O1CCOCC1>>[ClH:21].[NH2:8][CH2:9][CH2:10][O:11][C:12]1[C:16]2[CH:17]=[C:18]([Cl:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1

참가 물질

반응물 2

HCID 154539363-(2-(N-t-Butoxycarbonylamino)ethoxy)-5-chloro-1,2-benzisoxazole

HCID 204431481,4-Dioxane hydrochloride

생성물 1

HCID 186960233-(2-Aminoethoxy)-5-chloro-1,2-benzisoxazole hydrochloride수율 190.8%

실험 절차

To 3-(2-(N-t-butoxycarbonylamino)-ethoxy)-5-chloro-1,2-benzisoxazole (0.50 g) was added a solution of 4 N-hydrochloric acid/1,4-dioxane (4.0 ml) and stirred at room temperature for 15 minutes. After filtering the precipitated crystals and washing with 1,4-dioxane, the title compound (0.38 g) was obtained as colorless crystals.

후처리

filtrationAfter filtering the precipitated crystals
washwashing with 1,4-dioxane

출처 및 근거

ORD 기록: ord-5d1bc17ec8e94ee3be2cf1a1818d5cf0
출처 데이터셋: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06096771

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